Assay Detail
Functional
CHEMBL961819
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at human D2 like receptor expressed in HEK293 cells assessed as inhibition of quinpirole-stimulated mitogenesis
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
N-(4-(4-(2,3-dichloro- or 2-methoxyphenyl)piperazin-1-yl)butyl)heterobiarylcarboxamides with functionalized linking chains as high affinity and enantioselective D3 receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 6.74 | 8.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL124444 | — | — | 1 | 8.09 |
| CHEMBL424294 | — | — | 1 | 7.67 |
| CHEMBL1627324 | — | — | 1 | 7.64 |
| CHEMBL1627304 | — | — | 1 | 7.24 |
| CHEMBL59725 | — | — | 1 | 7.02 |
| CHEMBL366904 | — | — | 1 | 6.96 |
| CHEMBL139926 | — | — | 1 | 6.93 |
| CHEMBL1627320 | — | — | 1 | 6.83 |
| CHEMBL1627309 | — | — | 1 | 6.79 |
| CHEMBL182379 | — | — | 1 | 6.77 |
| CHEMBL1627323 | — | — | 1 | 6.76 |
| CHEMBL175734 | — | — | 1 | 6.59 |
| CHEMBL1627311 | — | — | 1 | 6.57 |
| CHEMBL1627321 | — | — | 1 | 6.47 |
| CHEMBL1627319 | — | — | 1 | 6.39 |
| CHEMBL1627308 | — | — | 1 | 6.37 |
| CHEMBL184383 | — | — | 1 | 5.99 |
| CHEMBL1627310 | — | — | 1 | 5.67 |
| CHEMBL1627305 | — | — | 1 | 5.36 |
| CHEMBL1627307 | — | — | 1 | - |
| CHEMBL1627306 | — | — | 1 | - |
| CHEMBL1627314 | — | — | 1 | - |
| CHEMBL1627315 | — | — | 1 | - |
| CHEMBL1627316 | — | — | 1 | - |
| CHEMBL1627317 | — | — | 1 | - |
| CHEMBL1627318 | — | — | 1 | - |
| CHEMBL1627312 | — | — | 1 | - |
| CHEMBL1627313 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL124444 | — | IC50 | = | 8.2 | nM | 8.09 |
| CHEMBL424294 | — | IC50 | = | 21.4 | nM | 7.67 |
| CHEMBL1627324 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL1627304 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL59725 | — | IC50 | = | 94.7 | nM | 7.02 |
| CHEMBL366904 | — | IC50 | = | 111.0 | nM | 6.96 |
| CHEMBL139926 | — | IC50 | = | 118.0 | nM | 6.93 |
| CHEMBL1627320 | — | IC50 | = | 146.1 | nM | 6.83 |
| CHEMBL1627309 | — | IC50 | = | 162.0 | nM | 6.79 |
| CHEMBL182379 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL1627323 | — | IC50 | = | 175.0 | nM | 6.76 |
| CHEMBL175734 | — | IC50 | = | 254.0 | nM | 6.59 |
| CHEMBL1627311 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL1627321 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL1627319 | — | IC50 | = | 405.0 | nM | 6.39 |
| CHEMBL1627308 | — | IC50 | = | 427.0 | nM | 6.37 |
| CHEMBL184383 | — | IC50 | = | 1030.0 | nM | 5.99 |
| CHEMBL1627310 | — | IC50 | = | 2160.0 | nM | 5.67 |
| CHEMBL1627305 | — | IC50 | = | 4370.0 | nM | 5.36 |
| CHEMBL1627307 | — | IC50 | - | — | - | |
| CHEMBL1627306 | — | IC50 | - | — | - | |
| CHEMBL1627314 | — | IC50 | - | — | - | |
| CHEMBL1627315 | — | IC50 | - | — | - | |
| CHEMBL1627316 | — | IC50 | - | — | - | |
| CHEMBL1627317 | — | IC50 | - | — | - | |
| CHEMBL1627318 | — | IC50 | - | — | - | |
| CHEMBL1627312 | — | IC50 | - | — | - | |
| CHEMBL1627313 | — | IC50 | - | — | - |