Assay Detail
Functional
CHEMBL961827
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human D3 receptor expressed in HEK293 cells assessed as stimulation of mitogenesis
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
N-(4-(4-(2,3-dichloro- or 2-methoxyphenyl)piperazin-1-yl)butyl)heterobiarylcarboxamides with functionalized linking chains as high affinity and enantioselective D3 receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 7.36 | 7.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1627316 | — | — | 1 | 7.64 |
| CHEMBL1627318 | — | — | 1 | 7.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1627316 | — | EC50 | = | 22.8 | nM | 7.64 |
| CHEMBL1627318 | — | EC50 | = | 84.0 | nM | 7.08 |