Assay Detail
Functional
CHEMBL962001
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Antiplasmodial activity after 48 hrs against chloroquine and pyrimethamine-resistant Plasmodium falciparum K1 in human erythrocytes by [3H]hypoxanthine uptake
50
Total Activities
50
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Quinuclidine derivatives as potential antiparasitics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 50 | 5.38 | 6.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL478532 | — | — | 1 | 6.22 |
| CHEMBL478723 | — | — | 1 | 6.22 |
| CHEMBL477326 | — | — | 1 | 6.22 |
| CHEMBL479211 | — | — | 1 | 6.16 |
| CHEMBL478358 | — | — | 1 | 6.10 |
| CHEMBL517057 | — | — | 1 | 6.05 |
| CHEMBL477492 | — | — | 1 | 5.96 |
| CHEMBL478724 | — | — | 1 | 5.96 |
| CHEMBL517819 | — | — | 1 | 5.85 |
| CHEMBL478112 | — | — | 1 | 5.77 |
| CHEMBL506873 | — | — | 1 | 5.75 |
| CHEMBL478339 | — | — | 1 | 5.72 |
| CHEMBL515183 | — | — | 1 | 5.70 |
| CHEMBL517050 | — | — | 1 | 5.68 |
| CHEMBL477322 | — | — | 1 | 5.57 |
| CHEMBL99679 | — | — | 1 | 5.55 |
| CHEMBL478533 | — | — | 1 | 5.52 |
| CHEMBL506578 | — | — | 1 | 5.51 |
| CHEMBL391926 | — | — | 1 | 5.48 |
| CHEMBL443678 | — | — | 1 | 5.40 |
| CHEMBL518134 | — | — | 1 | 5.39 |
| CHEMBL505301 | — | — | 1 | 5.37 |
| CHEMBL453439 | — | — | 1 | 5.32 |
| CHEMBL477327 | — | — | 1 | 5.30 |
| CHEMBL477079 | — | — | 1 | 5.28 |
| CHEMBL478913 | — | — | 1 | 5.27 |
| CHEMBL479212 | — | — | 1 | 5.23 |
| CHEMBL109405 | — | — | 1 | 5.21 |
| CHEMBL477305 | — | — | 1 | 5.19 |
| CHEMBL478349 | — | — | 1 | 5.15 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL478532 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL477326 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL478723 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL479211 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL478358 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL517057 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL477492 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL478724 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL517819 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL478112 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL506873 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL478339 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL515183 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL517050 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL477322 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL99679 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL478533 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL506578 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL391926 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL443678 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL518134 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL505301 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL453439 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL477327 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL477079 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL478913 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL479212 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL109405 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL477305 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL478349 | — | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL516436 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL478981 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL478530 | — | IC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL478912 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL478348 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL518600 | — | IC50 | = | 10200.0 | nM | 4.99 |
| CHEMBL516895 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL478531 | — | IC50 | = | 10900.0 | nM | 4.96 |
| CHEMBL259665 | — | IC50 | = | 11600.0 | nM | 4.94 |
| CHEMBL478347 | — | IC50 | = | 11700.0 | nM | 4.93 |
| CHEMBL344327 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL504277 | — | IC50 | = | 12300.0 | nM | 4.91 |
| CHEMBL479189 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL2094001 | — | IC50 | = | 14200.0 | nM | 4.85 |
| CHEMBL478340 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL442578 | — | IC50 | = | 18700.0 | nM | 4.73 |
| CHEMBL445817 | — | IC50 | = | 18900.0 | nM | 4.72 |
| CHEMBL479223 | — | IC50 | > | 18400.0 | nM | - |
| CHEMBL478359 | — | IC50 | > | 22000.0 | nM | - |
| CHEMBL478350 | — | IC50 | > | 21000.0 | nM | - |