Assay Detail
Binding
CHEMBL962087
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant Aurora A
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis, and biological evaluation of novel 3-aryl-4-(1H-indole-3yl)-1,5-dihydro-2H-pyrrole-2-ones as vascular endothelial growth factor receptor (VEGF-R) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 4.89 | 5.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL509435 | — | — | 1 | 5.50 |
| CHEMBL521201 | — | — | 1 | 5.50 |
| CHEMBL201511 | MALEIMIDE | — | 1 | 5.27 |
| CHEMBL488811 | — | — | 1 | 5.19 |
| CHEMBL452812 | — | — | 1 | 4.80 |
| CHEMBL529663 | — | — | 1 | 4.80 |
| CHEMBL529217 | — | — | 1 | 4.54 |
| CHEMBL488646 | — | — | 1 | 4.52 |
| CHEMBL488645 | — | — | 1 | 4.48 |
| CHEMBL453593 | — | — | 1 | 4.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL509435 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL521201 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL201511 | MALEIMIDE | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL488811 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL452812 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL529663 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL529217 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL488646 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL488645 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL453593 | — | IC50 | = | 47000.0 | nM | 4.33 |