Assay Detail
Binding
CHEMBL962323
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human corpus cavernosum PDE5 by scintillation proximity assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
cGMP-specific 3',5'-cyclic phosphodiesterase (CHEMBL1827) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Highly potent and selective chiral inhibitors of PDE5: an illustration of Pfeiffer's rule.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 8.07 | 9.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL444157 | — | — | 1 | 9.21 |
| CHEMBL514435 | — | — | 1 | 9.05 |
| CHEMBL1928257 | — | — | 1 | 8.96 |
| CHEMBL209157 | — | — | 1 | 8.89 |
| CHEMBL455187 | — | — | 1 | 8.52 |
| CHEMBL192 | SILDENAFIL | 4.0 | 1 | 8.46 |
| CHEMBL460293 | — | — | 1 | 8.38 |
| CHEMBL460294 | — | — | 1 | 8.25 |
| CHEMBL455452 | — | — | 1 | 8.11 |
| CHEMBL455412 | — | — | 1 | 7.11 |
| CHEMBL459047 | — | — | 1 | 7.10 |
| CHEMBL455413 | — | — | 1 | 7.00 |
| CHEMBL445457 | — | — | 1 | 7.00 |
| CHEMBL514433 | — | — | 1 | 7.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL444157 | — | IC50 | = | 0.62 | nM | 9.21 |
| CHEMBL514435 | — | IC50 | = | 0.89 | nM | 9.05 |
| CHEMBL1928257 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL209157 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL455187 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL192 | SILDENAFIL | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL460293 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL460294 | — | IC50 | = | 5.6 | nM | 8.25 |
| CHEMBL455452 | — | IC50 | = | 7.7 | nM | 8.11 |
| CHEMBL455412 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL459047 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL455413 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL445457 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL514433 | — | IC50 | = | 100.0 | nM | 7.00 |