Assay Detail
Binding
CHEMBL962325
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of canine retina PDE6 by scintillation proximity assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Canis lupus familiaris |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha (CHEMBL5151) ↗| Type | SINGLE PROTEIN |
| Organism | Canis lupus familiaris |
Publication
Highly potent and selective chiral inhibitors of PDE5: an illustration of Pfeiffer's rule.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.78 | 6.13 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL514435 | — | — | 1 | 6.13 |
| CHEMBL460294 | — | — | 1 | 5.90 |
| CHEMBL444157 | — | — | 1 | 5.81 |
| CHEMBL460293 | — | — | 1 | 5.70 |
| CHEMBL455187 | — | — | 1 | 5.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL514435 | — | IC50 | = | 734.0 | nM | 6.13 |
| CHEMBL460294 | — | IC50 | = | 1249.0 | nM | 5.90 |
| CHEMBL444157 | — | IC50 | = | 1539.0 | nM | 5.81 |
| CHEMBL460293 | — | IC50 | = | 1978.0 | nM | 5.70 |
| CHEMBL455187 | — | IC50 | = | 4323.0 | nM | 5.36 |