Assay Detail
Binding
CHEMBL962554
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Displacement of [3H]GR-113808 from human 5HT4 isoform E receptor expressed in rat C6 cells by liquid scintillation counting
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | C6 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis, and biological evaluation of new 5-HT4 receptor agonists: application as amyloid cascade modulators and potential therapeutic utility in Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 7.72 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL488325 | — | — | 1 | 8.70 |
| CHEMBL286136 | — | — | 1 | 8.30 |
| CHEMBL490852 | — | — | 1 | 8.30 |
| CHEMBL490050 | — | — | 1 | 7.92 |
| CHEMBL442869 | — | — | 1 | 7.85 |
| CHEMBL452353 | — | — | 1 | 6.96 |
| CHEMBL39 | SEROTONIN | 3.0 | 1 | 5.98 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL488325 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL286136 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL490852 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL490050 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL442869 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL452353 | — | Ki | = | 111.0 | nM | 6.96 |
| CHEMBL39 | SEROTONIN | Ki | = | 1049.0 | nM | 5.98 |