Assay Detail
Functional
CHEMBL962884
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Growth inhibition of human HepG2 cells after 72 hrs by SRB assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Tenacigenin B derivatives reverse P-glycoprotein-mediated multidrug resistance inHepG2/Dox cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.82 | 9.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 9.59 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 8.23 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.77 |
| CHEMBL469912 | PUROMYCIN | 2.0 | 1 | 6.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL159 | VINBLASTINE | IC50 | = | 0.26 | nM | 9.59 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 5.9 | nM | 8.23 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL469912 | PUROMYCIN | IC50 | = | 210.0 | nM | 6.68 |