Assay Detail
Binding
CHEMBL962981
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant PLA2g7 transfected in HEK293T cells by SDS-PAGE using rhodamine-tagged FP probe
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | HEK-293T |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Platelet-activating factor acetylhydrolase (CHEMBL3514) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Selectivity of inhibitors of endocannabinoid biosynthesis evaluated by activity-based protein profiling.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.13 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL175247 | ORLISTAT | 4.0 | 1 | 7.30 |
| CHEMBL158897 | — | — | 1 | 4.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL175247 | ORLISTAT | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL158897 | — | IC50 | = | 11000.0 | nM | 4.96 |