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Assay Detail

CHEMBL963012

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human recombinant SHP1
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Tyrosine-protein phosphatase non-receptor type 6 (CHEMBL3166)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Oleanolic acid and its derivatives: new inhibitor of protein tyrosine phosphatase 1B with cellular activities.
Zhang YN, Zhang W, Hong D, Shi L, Shen Q, Li JY, Li J, Hu LH.
Bioorg Med Chem (2008) 16 : 8697 -8705
PubMed 18707891 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 11 5.12 6.15

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL507502 1 6.15
CHEMBL499413 1 6.05
CHEMBL508831 1 5.39
CHEMBL509443 1 5.39
CHEMBL472401 1 5.28
CHEMBL211369 1 4.91
CHEMBL449613 1 4.90
CHEMBL391533 COROSOLIC ACID 1 4.61
CHEMBL169 URSOLIC ACID 2.0 1 4.59
CHEMBL472400 1 4.56
CHEMBL168 OLEANOLIC_ACID 1 4.50

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL507502 IC50 = 710.0 nM 6.15
CHEMBL499413 IC50 = 890.0 nM 6.05
CHEMBL508831 IC50 = 4050.0 nM 5.39
CHEMBL509443 IC50 = 4080.0 nM 5.39
CHEMBL472401 IC50 = 5200.0 nM 5.28
CHEMBL211369 IC50 = 12360.0 nM 4.91
CHEMBL449613 IC50 = 12640.0 nM 4.90
CHEMBL391533 COROSOLIC ACID IC50 = 24560.0 nM 4.61
CHEMBL169 URSOLIC ACID IC50 = 25780.0 nM 4.59
CHEMBL472400 IC50 = 27380.0 nM 4.56
CHEMBL168 OLEANOLIC_ACID IC50 = 31330.0 nM 4.50