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Assay Detail

CHEMBL963041

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Equilibrium binding affinity to wild type human PNP
10
Total Activities
10
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Purine nucleoside phosphorylase (CHEMBL4338)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Immucillins in custom catalytic-site cavities.
Murkin AS, Clinch K, Mason JM, Tyler PC, Schramm VL.
Bioorg Med Chem Lett (2008) 18 : 5900 -5903
PubMed 18778937 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 5 10.64 10.97
Activity 5 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL269864 ULODESINE 2.0 1 10.97
CHEMBL514795 1 10.71
CHEMBL218291 FORODESINE 4.0 1 10.24
CHEMBL462398 1 -
CHEMBL505564 1 -
CHEMBL512051 1 -
CHEMBL461527 1 -
CHEMBL443968 1 -
CHEMBL474328 1 -
CHEMBL473929 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL269864 ULODESINE Ki = 0.0107 nM 10.97
CHEMBL514795 Ki = 0.0196 nM 10.71
CHEMBL218291 FORODESINE Ki = 0.0579 nM 10.24
CHEMBL462398 Activity - -
CHEMBL505564 Ki = 0.0052 nM -
CHEMBL512051 Activity - -
CHEMBL461527 Activity - -
CHEMBL443968 Ki = 0.0098 nM -
CHEMBL474328 Activity - -
CHEMBL473929 Activity - -