Assay Detail
Functional
CHEMBL963092
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Antagonist activity at human EP3 receptor assessed as cAMP production by cell-based assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Prostaglandin E2 receptor EP3 subtype (CHEMBL3710) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
3,4-Disubstituted indole acylsulfonamides: a novel series of potent and selective human EP3 receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 9.26 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL519598 | — | — | 1 | 9.52 |
| CHEMBL480809 | — | — | 1 | 9.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL519598 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL480809 | — | IC50 | = | 1.0 | nM | 9.00 |