Assay Detail
Binding
CHEMBL963128
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Inhibition of MEK-mediated phosphorylation of myelin basic protein by kinase cascade assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
The discovery of the benzhydroxamate MEK inhibitors CI-1040 and PD 0325901.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 7.54 | 8.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL105442 | CI-1040 | 2.0 | 1 | 8.64 |
| CHEMBL510244 | — | — | 1 | 8.55 |
| CHEMBL455839 | — | — | 1 | 8.24 |
| CHEMBL519419 | — | — | 1 | 8.17 |
| CHEMBL453890 | — | — | 1 | 8.15 |
| CHEMBL454114 | — | — | 1 | 8.11 |
| CHEMBL511056 | — | — | 1 | 8.10 |
| CHEMBL510625 | — | — | 1 | 8.00 |
| CHEMBL455472 | — | — | 1 | 7.89 |
| CHEMBL446522 | — | — | 1 | 7.82 |
| CHEMBL454880 | — | — | 1 | 7.75 |
| CHEMBL442641 | — | — | 1 | 7.70 |
| CHEMBL454115 | — | — | 1 | 7.64 |
| CHEMBL448323 | — | — | 1 | 7.58 |
| CHEMBL455471 | — | — | 1 | 7.57 |
| CHEMBL455470 | — | — | 1 | 7.46 |
| CHEMBL454116 | — | — | 1 | 7.32 |
| CHEMBL487237 | — | — | 1 | 6.78 |
| CHEMBL488252 | — | — | 1 | 6.41 |
| CHEMBL520226 | — | — | 1 | 6.29 |
| CHEMBL488090 | — | — | 1 | 6.26 |
| CHEMBL505548 | — | — | 1 | 5.52 |
| CHEMBL23971 | — | — | 1 | - |
| CHEMBL488253 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL105442 | CI-1040 | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL510244 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL455839 | — | IC50 | = | 5.8 | nM | 8.24 |
| CHEMBL519419 | — | IC50 | = | 6.8 | nM | 8.17 |
| CHEMBL453890 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL454114 | — | IC50 | = | 7.8 | nM | 8.11 |
| CHEMBL511056 | — | IC50 | = | 7.96 | nM | 8.10 |
| CHEMBL510625 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL455472 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL446522 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL454880 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL442641 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL454115 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL448323 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL455471 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL455470 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL454116 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL487237 | — | IC50 | = | 166.0 | nM | 6.78 |
| CHEMBL488252 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL520226 | — | IC50 | = | 518.0 | nM | 6.29 |
| CHEMBL488090 | — | IC50 | = | 554.0 | nM | 6.26 |
| CHEMBL505548 | — | IC50 | = | 3050.0 | nM | 5.52 |
| CHEMBL23971 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL488253 | — | IC50 | > | 10000.0 | nM | - |