Assay Detail
Functional
CHEMBL963296
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at NTR1 expressed in CHOK1 cells by calcium mobilization assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | CHO-K1 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
The identification of nonpeptide neurotensin receptor partial agonists from the potent antagonist SR48692 using a calcium mobilization assay.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 6.81 | 9.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL407196 | NEUROTENSIN | — | 1 | 9.64 |
| CHEMBL508044 | — | — | 1 | 7.17 |
| CHEMBL463811 | — | — | 1 | 6.75 |
| CHEMBL294989 | — | — | 1 | 6.67 |
| CHEMBL462830 | — | — | 1 | 6.66 |
| CHEMBL463227 | — | — | 1 | 6.01 |
| CHEMBL518675 | — | — | 1 | 5.92 |
| CHEMBL464011 | — | — | 1 | 5.69 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL407196 | NEUROTENSIN | EC50 | = | 0.23 | nM | 9.64 |
| CHEMBL508044 | — | EC50 | = | 67.0 | nM | 7.17 |
| CHEMBL463811 | — | EC50 | = | 178.0 | nM | 6.75 |
| CHEMBL294989 | — | EC50 | = | 216.0 | nM | 6.67 |
| CHEMBL462830 | — | EC50 | = | 220.0 | nM | 6.66 |
| CHEMBL463227 | — | EC50 | = | 986.0 | nM | 6.01 |
| CHEMBL518675 | — | EC50 | = | 1214.0 | nM | 5.92 |
| CHEMBL464011 | — | EC50 | = | 2043.0 | nM | 5.69 |