Assay Detail
Functional
CHEMBL963340
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human SKOV3 cells after 72 hrs by SRB assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SK-OV-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of novel fluorinated docetaxel analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 9.55 | 11.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL503146 | — | — | 1 | 11.00 |
| CHEMBL504290 | — | — | 1 | 10.70 |
| CHEMBL501144 | — | — | 1 | 10.52 |
| CHEMBL510311 | — | — | 1 | 10.30 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 8.47 |
| CHEMBL446326 | — | — | 1 | 8.42 |
| CHEMBL499248 | — | — | 1 | 7.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL503146 | — | IC50 | = | 0.01 | nM | 11.00 |
| CHEMBL504290 | — | IC50 | = | 0.02 | nM | 10.70 |
| CHEMBL501144 | — | IC50 | = | 0.03 | nM | 10.52 |
| CHEMBL510311 | — | IC50 | = | 0.05 | nM | 10.30 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL446326 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL499248 | — | IC50 | = | 34.0 | nM | 7.47 |