Assay Detail
Binding
CHEMBL963374
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Inhibition of human GSK3-beta by scintillation counting
40
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
From a natural product lead to the identification of potent and selective benzofuran-3-yl-(indol-3-yl)maleimides as glycogen synthase kinase 3beta inhibitors that suppress proliferation and survival of pancreatic cancer cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 40 | 7.40 | 9.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL491647 | — | — | 1 | 9.64 |
| CHEMBL477038 | — | — | 1 | 9.46 |
| CHEMBL489833 | — | — | 1 | 9.29 |
| CHEMBL490636 | — | — | 1 | 9.14 |
| CHEMBL522590 | — | — | 1 | 9.02 |
| CHEMBL490842 | — | — | 1 | 8.92 |
| CHEMBL489210 | — | — | 1 | 8.46 |
| CHEMBL491447 | — | — | 1 | 8.29 |
| CHEMBL522464 | — | — | 1 | 8.27 |
| CHEMBL489422 | — | — | 1 | 8.15 |
| CHEMBL505673 | — | — | 1 | 8.12 |
| CHEMBL490637 | — | — | 1 | 7.99 |
| CHEMBL490861 | — | — | 1 | 7.88 |
| CHEMBL503469 | — | — | 1 | 7.82 |
| CHEMBL484685 | — | — | 1 | 7.79 |
| CHEMBL516261 | — | — | 1 | 7.62 |
| CHEMBL489435 | — | — | 1 | 7.60 |
| CHEMBL522751 | — | — | 1 | 7.46 |
| CHEMBL301138 | — | — | 1 | 7.46 |
| CHEMBL523113 | — | — | 1 | 7.38 |
| CHEMBL259850 | — | — | 1 | 7.38 |
| CHEMBL489845 | — | — | 1 | 7.32 |
| CHEMBL102714 | SB-216763 | — | 1 | 7.30 |
| CHEMBL489410 | — | — | 1 | 7.26 |
| CHEMBL489043 | — | — | 1 | 7.05 |
| CHEMBL490860 | — | — | 1 | 6.75 |
| CHEMBL489407 | — | — | 1 | 6.74 |
| CHEMBL520147 | — | — | 1 | 6.65 |
| CHEMBL491064 | — | — | 1 | 6.63 |
| CHEMBL523435 | — | — | 1 | 6.61 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL491647 | — | IC50 | = | 0.23 | nM | 9.64 |
| CHEMBL477038 | — | IC50 | = | 0.35 | nM | 9.46 |
| CHEMBL489833 | — | IC50 | = | 0.51 | nM | 9.29 |
| CHEMBL490636 | — | IC50 | = | 0.73 | nM | 9.14 |
| CHEMBL522590 | — | IC50 | = | 0.95 | nM | 9.02 |
| CHEMBL490842 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL489210 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL491447 | — | IC50 | = | 5.1 | nM | 8.29 |
| CHEMBL522464 | — | IC50 | = | 5.4 | nM | 8.27 |
| CHEMBL489422 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL505673 | — | IC50 | = | 7.5 | nM | 8.12 |
| CHEMBL490637 | — | IC50 | = | 10.2 | nM | 7.99 |
| CHEMBL490861 | — | IC50 | = | 13.2 | nM | 7.88 |
| CHEMBL503469 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL484685 | — | IC50 | = | 16.1 | nM | 7.79 |
| CHEMBL516261 | — | IC50 | = | 23.8 | nM | 7.62 |
| CHEMBL489435 | — | IC50 | = | 25.3 | nM | 7.60 |
| CHEMBL522751 | — | IC50 | = | 34.5 | nM | 7.46 |
| CHEMBL301138 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL259850 | — | IC50 | = | 41.8 | nM | 7.38 |
| CHEMBL523113 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL489845 | — | IC50 | = | 48.3 | nM | 7.32 |
| CHEMBL102714 | SB-216763 | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL489410 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL489043 | — | IC50 | = | 88.7 | nM | 7.05 |
| CHEMBL490860 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL489407 | — | IC50 | = | 184.0 | nM | 6.74 |
| CHEMBL520147 | — | IC50 | = | 223.0 | nM | 6.65 |
| CHEMBL491064 | — | IC50 | = | 235.0 | nM | 6.63 |
| CHEMBL523435 | — | IC50 | = | 247.0 | nM | 6.61 |
| CHEMBL522760 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL491859 | — | IC50 | = | 314.0 | nM | 6.50 |
| CHEMBL490044 | — | IC50 | = | 335.0 | nM | 6.47 |
| CHEMBL483669 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL483465 | ELRAGLUSIB | IC50 | = | 710.0 | nM | 6.15 |
| CHEMBL482632 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL521774 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL490639 | — | IC50 | = | 1290.0 | nM | 5.89 |
| CHEMBL489413 | — | IC50 | = | 4090.0 | nM | 5.39 |
| CHEMBL489421 | — | IC50 | = | 7160.0 | nM | 5.14 |