Assay Detail
Binding
CHEMBL963375
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Inhibition of CDK2/Cyclin E
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
From a natural product lead to the identification of potent and selective benzofuran-3-yl-(indol-3-yl)maleimides as glycogen synthase kinase 3beta inhibitors that suppress proliferation and survival of pancreatic cancer cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 6.02 | 8.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL388978 | STAUROSPORINE | — | 1 | 8.42 |
| CHEMBL491447 | — | — | 1 | 7.57 |
| CHEMBL522464 | — | — | 1 | 6.83 |
| CHEMBL477038 | — | — | 1 | 6.62 |
| CHEMBL489833 | — | — | 1 | 6.47 |
| CHEMBL522751 | — | — | 1 | 5.97 |
| CHEMBL505673 | — | — | 1 | 5.94 |
| CHEMBL301138 | — | — | 1 | 5.85 |
| CHEMBL523113 | — | — | 1 | 5.74 |
| CHEMBL491647 | — | — | 1 | 5.41 |
| CHEMBL522590 | — | — | 1 | 4.93 |
| CHEMBL491064 | — | — | 1 | 4.50 |
| CHEMBL522760 | — | — | 1 | 4.00 |
| CHEMBL523435 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL388978 | STAUROSPORINE | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL491447 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL522464 | — | IC50 | = | 149.0 | nM | 6.83 |
| CHEMBL477038 | — | IC50 | = | 237.0 | nM | 6.62 |
| CHEMBL489833 | — | IC50 | = | 337.0 | nM | 6.47 |
| CHEMBL522751 | — | IC50 | = | 1070.0 | nM | 5.97 |
| CHEMBL505673 | — | IC50 | = | 1160.0 | nM | 5.94 |
| CHEMBL301138 | — | IC50 | = | 1410.0 | nM | 5.85 |
| CHEMBL523113 | — | IC50 | = | 1840.0 | nM | 5.74 |
| CHEMBL491647 | — | IC50 | = | 3880.0 | nM | 5.41 |
| CHEMBL522590 | — | IC50 | = | 11700.0 | nM | 4.93 |
| CHEMBL491064 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL522760 | — | IC50 | = | 99000.0 | nM | 4.00 |
| CHEMBL523435 | — | IC50 | > | 50000.0 | nM | - |