Assay Detail
Binding
CHEMBL963380
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Inhibition of CDK4/Cyclin D1
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Cyclin-dependent kinase 4/cyclin D1 (CHEMBL1907601) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
From a natural product lead to the identification of potent and selective benzofuran-3-yl-(indol-3-yl)maleimides as glycogen synthase kinase 3beta inhibitors that suppress proliferation and survival of pancreatic cancer cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.55 | 7.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL388978 | STAUROSPORINE | — | 1 | 7.74 |
| CHEMBL489833 | — | — | 1 | 5.97 |
| CHEMBL491647 | — | — | 1 | 5.06 |
| CHEMBL522590 | — | — | 1 | 4.74 |
| CHEMBL522760 | — | — | 1 | 4.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL388978 | STAUROSPORINE | IC50 | = | 18.3 | nM | 7.74 |
| CHEMBL489833 | — | IC50 | = | 1080.0 | nM | 5.97 |
| CHEMBL491647 | — | IC50 | = | 8620.0 | nM | 5.06 |
| CHEMBL522590 | — | IC50 | = | 18300.0 | nM | 4.74 |
| CHEMBL522760 | — | IC50 | = | 59500.0 | nM | 4.22 |