Assay Detail
Binding
CHEMBL963381
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Inhibition of CDK5/P25
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Cyclin-dependent kinase 5/CDK5 activator 1 (CHEMBL1907600) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
From a natural product lead to the identification of potent and selective benzofuran-3-yl-(indol-3-yl)maleimides as glycogen synthase kinase 3beta inhibitors that suppress proliferation and survival of pancreatic cancer cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.99 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL388978 | STAUROSPORINE | — | 1 | 8.40 |
| CHEMBL489833 | — | — | 1 | 5.94 |
| CHEMBL491647 | — | — | 1 | 4.89 |
| CHEMBL522590 | — | — | 1 | 4.72 |
| CHEMBL522760 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL388978 | STAUROSPORINE | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL489833 | — | IC50 | = | 1160.0 | nM | 5.94 |
| CHEMBL491647 | — | IC50 | = | 12900.0 | nM | 4.89 |
| CHEMBL522590 | — | IC50 | = | 18900.0 | nM | 4.72 |
| CHEMBL522760 | — | IC50 | = | 108000.0 | nM | - |