Assay Detail
Functional
CHEMBL963393
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Growth inhibition of human MIAPaCa2 cells after 72 hrs by MTS assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MIA PaCa-2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
From a natural product lead to the identification of potent and selective benzofuran-3-yl-(indol-3-yl)maleimides as glycogen synthase kinase 3beta inhibitors that suppress proliferation and survival of pancreatic cancer cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 5.08 | 6.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL523435 | — | — | 1 | 6.22 |
| CHEMBL489043 | — | — | 1 | 5.70 |
| CHEMBL489407 | — | — | 1 | 5.52 |
| CHEMBL522760 | — | — | 1 | 5.52 |
| CHEMBL483465 | ELRAGLUSIB | 2.0 | 1 | 5.30 |
| CHEMBL522590 | — | — | 1 | 5.16 |
| CHEMBL522751 | — | — | 1 | 5.10 |
| CHEMBL482632 | — | — | 1 | 5.10 |
| CHEMBL491859 | — | — | 1 | 4.77 |
| CHEMBL102714 | SB-216763 | — | 1 | 4.60 |
| CHEMBL490860 | — | — | 1 | 4.55 |
| CHEMBL259850 | — | — | 1 | 4.54 |
| CHEMBL489422 | — | — | 1 | 4.52 |
| CHEMBL484685 | — | — | 1 | 4.47 |
| CHEMBL483669 | — | — | 1 | - |
| CHEMBL491647 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL523435 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL489043 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL489407 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL522760 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL483465 | ELRAGLUSIB | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL522590 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL522751 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL482632 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL491859 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL102714 | SB-216763 | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL490860 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL259850 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL489422 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL484685 | — | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL483669 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL491647 | — | IC50 | > | 50000.0 | nM | - |