Assay Detail
Functional
CHEMBL963394
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Growth inhibition of human BxPC3 cells after 72 hrs by MTS assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | BXPC-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
From a natural product lead to the identification of potent and selective benzofuran-3-yl-(indol-3-yl)maleimides as glycogen synthase kinase 3beta inhibitors that suppress proliferation and survival of pancreatic cancer cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 5.38 | 6.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL523435 | — | — | 1 | 6.05 |
| CHEMBL489043 | — | — | 1 | 6.05 |
| CHEMBL522760 | — | — | 1 | 6.00 |
| CHEMBL483465 | ELRAGLUSIB | 2.0 | 1 | 6.00 |
| CHEMBL489407 | — | — | 1 | 5.70 |
| CHEMBL522590 | — | — | 1 | 5.30 |
| CHEMBL482632 | — | — | 1 | 5.22 |
| CHEMBL491859 | — | — | 1 | 5.16 |
| CHEMBL259850 | — | — | 1 | 4.85 |
| CHEMBL522751 | — | — | 1 | 4.48 |
| CHEMBL490860 | — | — | 1 | 4.38 |
| CHEMBL102714 | SB-216763 | — | 1 | - |
| CHEMBL489422 | — | — | 1 | - |
| CHEMBL484685 | — | — | 1 | - |
| CHEMBL483669 | — | — | 1 | - |
| CHEMBL491647 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL523435 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL489043 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL522760 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL483465 | ELRAGLUSIB | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL489407 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL522590 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL482632 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL491859 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL259850 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL522751 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL490860 | — | IC50 | = | 42000.0 | nM | 4.38 |
| CHEMBL102714 | SB-216763 | IC50 | - | — | - | |
| CHEMBL489422 | — | IC50 | - | — | - | |
| CHEMBL484685 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL483669 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL491647 | — | IC50 | > | 50000.0 | nM | - |