Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL963822

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against Pgp deficient human MCF7 cells after 72 hrs by sulforhodamine B test
ChEMBL ↗
37
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type MCF7
Confidence 1 — Organism
Curated By Autocuration

Target

MCF7 (CHEMBL387) ↗
Type CELL-LINE
Organism Homo sapiens

Publication

Design, synthesis, and biological evaluation of new-generation taxoids.
Ojima I, Chen J, Sun L, Borella CP, Wang T, Miller ML, Lin S, Geng X, Kuznetsova L, Qu C, Gallager D, Zhao X, Zanardi I, Xia S, Horwitz SB, Mallen-St Clair J, Guerriero JL, Bar-Sagi D, Veith JM, Pera P, Bernacki RJ.
J Med Chem (2008) 51 : 3203 -3221
PubMed 18465846 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 37 9.15 9.77

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL501006 — — 1 9.77
CHEMBL126678 — — 1 9.74
CHEMBL126916 — — 1 9.70
CHEMBL507683 — — 1 9.70
CHEMBL502400 — — 1 9.52
CHEMBL506225 — — 1 9.52
CHEMBL420349 — — 1 9.46
CHEMBL467163 — — 1 9.44
CHEMBL450955 — — 1 9.44
CHEMBL453702 — — 1 9.40
CHEMBL444419 — — 1 9.40
CHEMBL510577 — — 1 9.40
CHEMBL447258 — — 1 9.30
CHEMBL509534 — — 1 9.22
CHEMBL504333 — — 1 9.22
CHEMBL503845 — — 1 9.15
CHEMBL498935 — — 1 9.10
CHEMBL362146 — — 1 9.10
CHEMBL502402 — — 1 9.10
CHEMBL502100 — — 1 9.10
CHEMBL445708 — — 1 9.05
CHEMBL3545252 DOCETAXEL 4.0 1 9.00
CHEMBL455233 — — 1 9.00
CHEMBL442936 — — 1 9.00
CHEMBL502942 — — 1 8.96
CHEMBL447645 — — 1 8.96
CHEMBL506159 — — 1 8.92
CHEMBL502482 — — 1 8.89
CHEMBL454522 — — 1 8.85
CHEMBL502986 — — 1 8.85

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL501006 — IC50 = 0.17 nM 9.77
CHEMBL126678 — IC50 = 0.18 nM 9.74
CHEMBL126916 — IC50 = 0.2 nM 9.70
CHEMBL507683 — IC50 = 0.2 nM 9.70
CHEMBL502400 — IC50 = 0.3 nM 9.52
CHEMBL506225 — IC50 = 0.3 nM 9.52
CHEMBL420349 — IC50 = 0.35 nM 9.46
CHEMBL467163 — IC50 = 0.36 nM 9.44
CHEMBL450955 — IC50 = 0.36 nM 9.44
CHEMBL453702 — IC50 = 0.4 nM 9.40
CHEMBL444419 — IC50 = 0.4 nM 9.40
CHEMBL510577 — IC50 = 0.4 nM 9.40
CHEMBL447258 — IC50 = 0.5 nM 9.30
CHEMBL509534 — IC50 = 0.6 nM 9.22
CHEMBL504333 — IC50 = 0.6 nM 9.22
CHEMBL503845 — IC50 = 0.7 nM 9.15
CHEMBL502100 — IC50 = 0.8 nM 9.10
CHEMBL502402 — IC50 = 0.8 nM 9.10
CHEMBL498935 — IC50 = 0.8 nM 9.10
CHEMBL362146 — IC50 = 0.8 nM 9.10
CHEMBL445708 — IC50 = 0.9 nM 9.05
CHEMBL3545252 DOCETAXEL IC50 = 1.0 nM 9.00
CHEMBL455233 — IC50 = 1.0 nM 9.00
CHEMBL442936 — IC50 = 1.0 nM 9.00
CHEMBL502942 — IC50 = 1.1 nM 8.96
CHEMBL447645 — IC50 = 1.1 nM 8.96
CHEMBL506159 — IC50 = 1.2 nM 8.92
CHEMBL502482 — IC50 = 1.3 nM 8.89
CHEMBL454522 — IC50 = 1.4 nM 8.85
CHEMBL502986 — IC50 = 1.4 nM 8.85
CHEMBL506777 — IC50 = 1.4 nM 8.85
CHEMBL450892 — IC50 = 1.44 nM 8.84
CHEMBL501707 — IC50 = 1.5 nM 8.82
CHEMBL428647 PACLITAXEL IC50 = 1.7 nM 8.77
CHEMBL502695 — IC50 = 1.8 nM 8.74
CHEMBL452738 — IC50 = 2.0 nM 8.70
CHEMBL503307 — IC50 = 2.3 nM 8.64