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Assay Detail

CHEMBL963830

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against multidrug resistant human MIAPaCa2 cells after 72 hrs by MTT assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type MIA PaCa-2
Confidence 1 — Organism
Curated By Autocuration

Target

MIA PaCa-2 (CHEMBL614725)
Type CELL-LINE
Organism Homo sapiens

Publication

Design, synthesis, and biological evaluation of new-generation taxoids.
Ojima I, Chen J, Sun L, Borella CP, Wang T, Miller ML, Lin S, Geng X, Kuznetsova L, Qu C, Gallager D, Zhao X, Zanardi I, Xia S, Horwitz SB, Mallen-St Clair J, Guerriero JL, Bar-Sagi D, Veith JM, Pera P, Bernacki RJ.
J Med Chem (2008) 51 : 3203 -3221
PubMed 18465846 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 2 9.11 9.17

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL450955 1 9.17
CHEMBL126916 1 9.04

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL450955 IC50 = 0.68 nM 9.17
CHEMBL126916 IC50 = 0.92 nM 9.04