Assay Detail
Binding
CHEMBL963848
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Inhibition of bovine PDE5
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
cGMP-specific 3',5'-cyclic phosphodiesterase (CHEMBL3478) ↗| Type | SINGLE PROTEIN |
| Organism | Bos taurus |
Publication
Quinazolines as potent and highly selective PDE5 inhibitors as potential therapeutics for male erectile dysfunction.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 7.63 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL521075 | — | — | 1 | 9.00 |
| CHEMBL512174 | — | — | 1 | 8.40 |
| CHEMBL471702 | — | — | 1 | 8.30 |
| CHEMBL473301 | — | — | 1 | 8.10 |
| CHEMBL192 | SILDENAFIL | 4.0 | 1 | 8.00 |
| CHEMBL488265 | — | — | 1 | 8.00 |
| CHEMBL470310 | — | — | 1 | 7.92 |
| CHEMBL779 | TADALAFIL | 4.0 | 1 | 7.92 |
| CHEMBL472559 | — | — | 1 | 7.92 |
| CHEMBL470492 | — | — | 1 | 7.85 |
| CHEMBL471703 | — | — | 1 | 7.85 |
| CHEMBL471529 | — | — | 1 | 7.75 |
| CHEMBL520074 | — | — | 1 | 7.75 |
| CHEMBL471701 | — | — | 1 | 7.72 |
| CHEMBL513593 | — | — | 1 | 7.72 |
| CHEMBL488080 | — | — | 1 | 7.68 |
| CHEMBL471528 | — | — | 1 | 7.54 |
| CHEMBL488091 | — | — | 1 | 7.50 |
| CHEMBL472558 | — | — | 1 | 7.50 |
| CHEMBL524871 | — | — | 1 | 7.15 |
| CHEMBL473507 | — | — | 1 | 6.24 |
| CHEMBL470311 | — | — | 1 | 5.96 |
| CHEMBL487247 | — | — | 1 | 5.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL521075 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL512174 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL471702 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL473301 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL192 | SILDENAFIL | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL488265 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL470310 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL779 | TADALAFIL | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL472559 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL470492 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL471703 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL471529 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL520074 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL471701 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL513593 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL488080 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL471528 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL488091 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL472558 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL524871 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL473507 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL470311 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL487247 | — | IC50 | = | 1600.0 | nM | 5.80 |