Assay Detail
Binding
CHEMBL963849
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Inhibition of bovine PDE6
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Quinazolines as potent and highly selective PDE5 inhibitors as potential therapeutics for male erectile dysfunction.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 5.78 | 6.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL192 | SILDENAFIL | 4.0 | 1 | 6.85 |
| CHEMBL471702 | — | — | 1 | 6.38 |
| CHEMBL512174 | — | — | 1 | 6.36 |
| CHEMBL521075 | — | — | 1 | 6.34 |
| CHEMBL520074 | — | — | 1 | 6.10 |
| CHEMBL471701 | — | — | 1 | 6.09 |
| CHEMBL488080 | — | — | 1 | 5.62 |
| CHEMBL471703 | — | — | 1 | 5.43 |
| CHEMBL471529 | — | — | 1 | 5.35 |
| CHEMBL488265 | — | — | 1 | 5.23 |
| CHEMBL513593 | — | — | 1 | 4.85 |
| CHEMBL779 | TADALAFIL | 4.0 | 1 | 4.74 |
| CHEMBL471528 | — | — | 1 | - |
| CHEMBL470492 | — | — | 1 | - |
| CHEMBL488091 | — | — | 1 | - |
| CHEMBL487247 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL192 | SILDENAFIL | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL471702 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL512174 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL521075 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL520074 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL471701 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL488080 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL471703 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL471529 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL488265 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL513593 | — | IC50 | = | 14100.0 | nM | 4.85 |
| CHEMBL779 | TADALAFIL | IC50 | = | 18100.0 | nM | 4.74 |
| CHEMBL471528 | — | IC50 | - | — | - | |
| CHEMBL470492 | — | IC50 | - | — | - | |
| CHEMBL488091 | — | IC50 | - | — | - | |
| CHEMBL487247 | — | IC50 | - | — | - |