Assay Detail
Binding
CHEMBL963880
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to MEK
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Beyond the MEK-pocket: can current MEK kinase inhibitors be utilized to synthesize novel type III NCKIs? Does the MEK-pocket exist in kinases other than MEK?
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 8.10 | 8.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL481949 | ZAPNOMETINIB | 2.0 | 1 | 8.24 |
| CHEMBL455839 | — | — | 1 | 7.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL481949 | ZAPNOMETINIB | IC50 | = | 5.73 | nM | 8.24 |
| CHEMBL455839 | — | IC50 | = | 11.0 | nM | 7.96 |