Assay Detail
Binding
CHEMBL964131
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Inhibition of ErbB2 by time resolved fluorescence assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Receptor tyrosine-protein kinase erbB-2 (CHEMBL1824) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Development of multitargeted inhibitors of both the insulin-like growth factor receptor (IGF-IR) and members of the epidermal growth factor family of receptor tyrosine kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 7.09 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL446250 | — | — | 1 | 7.89 |
| CHEMBL448628 | — | — | 1 | 7.77 |
| CHEMBL455208 | — | — | 1 | 7.36 |
| CHEMBL437584 | — | — | 1 | 7.28 |
| CHEMBL443098 | — | — | 1 | 7.27 |
| CHEMBL452717 | — | — | 1 | 7.23 |
| CHEMBL249496 | — | — | 1 | 6.73 |
| CHEMBL248877 | — | — | 1 | 6.60 |
| CHEMBL503638 | — | — | 1 | 6.57 |
| CHEMBL251732 | — | — | 1 | 6.18 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL446250 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL448628 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL455208 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL437584 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL443098 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL452717 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL249496 | — | IC50 | = | 186.0 | nM | 6.73 |
| CHEMBL248877 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL503638 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL251732 | — | IC50 | = | 664.0 | nM | 6.18 |