Assay Detail
Binding
CHEMBL964161
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Binding affinity to human sst1 receptor
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of novel non-peptidic beta-alanine piperazine amide derivatives and their optimization to achiral, easily accessible, potent and selective somatostatin sst1 receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 4 | 8.58 | 8.79 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL460542 | — | — | 1 | 8.79 |
| CHEMBL540705 | — | — | 1 | 8.67 |
| CHEMBL523814 | — | — | 1 | 8.58 |
| CHEMBL473763 | — | — | 1 | 8.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL460542 | — | Kd | = | 1.622 | nM | 8.79 |
| CHEMBL540705 | — | Kd | = | 2.138 | nM | 8.67 |
| CHEMBL523814 | — | Kd | = | 2.63 | nM | 8.58 |
| CHEMBL473763 | — | Kd | = | 5.37 | nM | 8.27 |