Assay Detail
Binding
CHEMBL964196
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of ErbB2 by HTRF assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Receptor tyrosine-protein kinase erbB-2 (CHEMBL1824) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and evaluation of aniline headgroups for alkynyl thienopyrimidine dual EGFR/ErbB-2 kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 6.91 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL510845 | — | — | 1 | 7.52 |
| CHEMBL500072 | — | — | 1 | 7.46 |
| CHEMBL507821 | — | — | 1 | 7.30 |
| CHEMBL508760 | — | — | 1 | 7.22 |
| CHEMBL500217 | — | — | 1 | 7.22 |
| CHEMBL455434 | — | — | 1 | 7.22 |
| CHEMBL507329 | GW869810X | — | 1 | 7.10 |
| CHEMBL451074 | — | — | 1 | 7.07 |
| CHEMBL455433 | — | — | 1 | 7.06 |
| CHEMBL503253 | — | — | 1 | 6.89 |
| CHEMBL451347 | — | — | 1 | 6.75 |
| CHEMBL505463 | — | — | 1 | 6.75 |
| CHEMBL452980 | — | — | 1 | 6.68 |
| CHEMBL457250 | — | — | 1 | 6.66 |
| CHEMBL452716 | — | — | 1 | 6.58 |
| CHEMBL461811 | — | — | 1 | 6.43 |
| CHEMBL449949 | — | — | 1 | 6.35 |
| CHEMBL501050 | — | — | 1 | 6.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL510845 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL500072 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL507821 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL508760 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL500217 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL455434 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL507329 | GW869810X | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL451074 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL455433 | — | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL503253 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL451347 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL505463 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL452980 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL457250 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL452716 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL461811 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL449949 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL501050 | — | IC50 | = | 800.0 | nM | 6.10 |