Assay Detail
Binding
CHEMBL964233
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Binding affinity at 5HT3 receptor
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Novel antagonists of serotonin-4 receptors: synthesis and biological evaluation of pyrrolothienopyrazines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 6.64 | 8.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL56564 | TROPISETRON | 3.0 | 1 | 8.55 |
| CHEMBL287045 | — | — | 1 | 6.90 |
| CHEMBL68131 | — | — | 1 | 6.80 |
| CHEMBL472219 | — | — | 1 | 6.60 |
| CHEMBL3084582 | — | — | 1 | 6.50 |
| CHEMBL83954 | — | — | 1 | 5.70 |
| CHEMBL117287 | PRUCALOPRIDE | 4.0 | 1 | 5.40 |
| CHEMBL33884 | — | — | 1 | - |
| CHEMBL356359 | PIBOSEROD | 2.0 | 1 | - |
| CHEMBL76370 | TEGASEROD | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL56564 | TROPISETRON | Ki | = | 2.818 | nM | 8.55 |
| CHEMBL287045 | — | Ki | = | 125.89 | nM | 6.90 |
| CHEMBL68131 | — | Ki | = | 158.49 | nM | 6.80 |
| CHEMBL472219 | — | Ki | = | 251.19 | nM | 6.60 |
| CHEMBL3084582 | — | Ki | = | 316.23 | nM | 6.50 |
| CHEMBL83954 | — | Ki | = | 1995.26 | nM | 5.70 |
| CHEMBL117287 | PRUCALOPRIDE | Ki | = | 3981.07 | nM | 5.40 |
| CHEMBL33884 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL356359 | PIBOSEROD | Ki | > | 1000.0 | nM | - |
| CHEMBL76370 | TEGASEROD | Ki | > | 10000.0 | nM | - |