Assay Detail
Binding
CHEMBL964384
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Inhibition of H+/K+ ATPase
40
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Orally active C-6 heteroaryl- and heterocyclyl-substituted imidazo[1,2-a]pyridine acid pump antagonists (APAs).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 40 | 6.81 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL496806 | — | — | 1 | 8.40 |
| CHEMBL496400 | — | — | 1 | 8.30 |
| CHEMBL523752 | — | — | 1 | 8.20 |
| CHEMBL453246 | — | — | 1 | 8.10 |
| CHEMBL496605 | — | — | 1 | 7.90 |
| CHEMBL496387 | — | — | 1 | 7.80 |
| CHEMBL496035 | — | — | 1 | 7.60 |
| CHEMBL496606 | — | — | 1 | 7.60 |
| CHEMBL496227 | — | — | 1 | 7.50 |
| CHEMBL498434 | — | — | 1 | 7.40 |
| CHEMBL447822 | — | — | 1 | 7.40 |
| CHEMBL495787 | — | — | 1 | 7.20 |
| CHEMBL496402 | — | — | 1 | 7.10 |
| CHEMBL496386 | — | — | 1 | 7.10 |
| CHEMBL498220 | — | — | 1 | 7.00 |
| CHEMBL238146 | — | — | 1 | 7.00 |
| CHEMBL523563 | — | — | 1 | 7.00 |
| CHEMBL496624 | — | — | 1 | 7.00 |
| CHEMBL521889 | — | — | 1 | 6.90 |
| CHEMBL510171 | — | — | 1 | 6.90 |
| CHEMBL497096 | — | — | 1 | 6.90 |
| CHEMBL498251 | — | — | 1 | 6.80 |
| CHEMBL495786 | — | — | 1 | 6.70 |
| CHEMBL498252 | — | — | 1 | 6.60 |
| CHEMBL497011 | LINAPRAZAN | 2.0 | 1 | 6.50 |
| CHEMBL496426 | — | — | 1 | 6.50 |
| CHEMBL498840 | — | — | 1 | 6.40 |
| CHEMBL498280 | — | — | 1 | 6.40 |
| CHEMBL498026 | — | — | 1 | 6.30 |
| CHEMBL526841 | — | — | 1 | 6.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL496806 | — | IC50 | = | 3.981 | nM | 8.40 |
| CHEMBL496400 | — | IC50 | = | 5.012 | nM | 8.30 |
| CHEMBL523752 | — | IC50 | = | 6.31 | nM | 8.20 |
| CHEMBL453246 | — | IC50 | = | 7.943 | nM | 8.10 |
| CHEMBL496605 | — | IC50 | = | 12.59 | nM | 7.90 |
| CHEMBL496387 | — | IC50 | = | 15.85 | nM | 7.80 |
| CHEMBL496035 | — | IC50 | = | 25.12 | nM | 7.60 |
| CHEMBL496606 | — | IC50 | = | 25.12 | nM | 7.60 |
| CHEMBL496227 | — | IC50 | = | 31.62 | nM | 7.50 |
| CHEMBL447822 | — | IC50 | = | 39.81 | nM | 7.40 |
| CHEMBL498434 | — | IC50 | = | 39.81 | nM | 7.40 |
| CHEMBL495787 | — | IC50 | = | 63.1 | nM | 7.20 |
| CHEMBL496402 | — | IC50 | = | 79.43 | nM | 7.10 |
| CHEMBL496386 | — | IC50 | = | 79.43 | nM | 7.10 |
| CHEMBL496624 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL498220 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL523563 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL238146 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL497096 | — | IC50 | = | 125.89 | nM | 6.90 |
| CHEMBL521889 | — | IC50 | = | 125.89 | nM | 6.90 |
| CHEMBL510171 | — | IC50 | = | 125.89 | nM | 6.90 |
| CHEMBL498251 | — | IC50 | = | 158.49 | nM | 6.80 |
| CHEMBL495786 | — | IC50 | = | 199.53 | nM | 6.70 |
| CHEMBL498252 | — | IC50 | = | 251.19 | nM | 6.60 |
| CHEMBL497011 | LINAPRAZAN | IC50 | = | 316.23 | nM | 6.50 |
| CHEMBL496426 | — | IC50 | = | 316.23 | nM | 6.50 |
| CHEMBL498840 | — | IC50 | = | 398.11 | nM | 6.40 |
| CHEMBL498280 | — | IC50 | = | 398.11 | nM | 6.40 |
| CHEMBL526841 | — | IC50 | = | 501.19 | nM | 6.30 |
| CHEMBL498026 | — | IC50 | = | 501.19 | nM | 6.30 |
| CHEMBL525001 | — | IC50 | = | 630.96 | nM | 6.20 |
| CHEMBL488539 | — | IC50 | = | 794.33 | nM | 6.10 |
| CHEMBL498114 | — | IC50 | = | 1258.93 | nM | 5.90 |
| CHEMBL497418 | — | IC50 | = | 1584.89 | nM | 5.80 |
| CHEMBL498278 | — | IC50 | = | 1995.26 | nM | 5.70 |
| CHEMBL521724 | — | IC50 | = | 2511.89 | nM | 5.60 |
| CHEMBL498279 | — | IC50 | = | 3981.07 | nM | 5.40 |
| CHEMBL497419 | — | IC50 | = | 5011.87 | nM | 5.30 |
| CHEMBL495999 | — | IC50 | = | 19952.62 | nM | 4.70 |
| CHEMBL496204 | — | IC50 | > | 100000.0 | nM | - |