Assay Detail
Binding
CHEMBL964401
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of H+/K+ ATPase in parietal cells assessed as inhibition of pentagastrin-stimulated [14C]aminopyrine accumulation
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Orally active C-6 heteroaryl- and heterocyclyl-substituted imidazo[1,2-a]pyridine acid pump antagonists (APAs).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.05 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL496387 | — | — | 1 | 7.30 |
| CHEMBL496605 | — | — | 1 | 7.30 |
| CHEMBL496606 | — | — | 1 | 7.20 |
| CHEMBL523563 | — | — | 1 | 7.20 |
| CHEMBL496624 | — | — | 1 | 7.10 |
| CHEMBL496035 | — | — | 1 | 7.00 |
| CHEMBL496227 | — | — | 1 | 6.80 |
| CHEMBL496386 | — | — | 1 | 6.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL496387 | — | IC50 | = | 50.12 | nM | 7.30 |
| CHEMBL496605 | — | IC50 | = | 50.12 | nM | 7.30 |
| CHEMBL496606 | — | IC50 | = | 63.1 | nM | 7.20 |
| CHEMBL523563 | — | IC50 | = | 63.1 | nM | 7.20 |
| CHEMBL496624 | — | IC50 | = | 79.43 | nM | 7.10 |
| CHEMBL496035 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL496227 | — | IC50 | = | 158.49 | nM | 6.80 |
| CHEMBL496386 | — | IC50 | = | 316.23 | nM | 6.50 |