Assay Detail
Binding
CHEMBL964693
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]nisoxetine from human NET expressed in HEK293 cells
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent noradrenaline transporter (CHEMBL222) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Carbon-11 labeled indolylpropylamine analog as a new potential PET agent for imaging of the serotonin transporter.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 5.66 | 6.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL520970 | — | — | 1 | 6.15 |
| CHEMBL482903 | — | — | 1 | 5.78 |
| CHEMBL519819 | — | — | 1 | 5.74 |
| CHEMBL503609 | — | — | 1 | 5.56 |
| CHEMBL520301 | — | — | 1 | 5.54 |
| CHEMBL483316 | — | — | 1 | 5.18 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL520970 | — | Ki | = | 712.0 | nM | 6.15 |
| CHEMBL482903 | — | Ki | = | 1680.0 | nM | 5.78 |
| CHEMBL519819 | — | Ki | = | 1810.0 | nM | 5.74 |
| CHEMBL503609 | — | Ki | = | 2770.0 | nM | 5.56 |
| CHEMBL520301 | — | Ki | = | 2880.0 | nM | 5.54 |
| CHEMBL483316 | — | Ki | = | 6600.0 | nM | 5.18 |