Assay Detail
Binding
CHEMBL964694
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Displacement of [3H]WIN-35428 from human DAT expressed in HEK293 cells
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent dopamine transporter (CHEMBL238) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Carbon-11 labeled indolylpropylamine analog as a new potential PET agent for imaging of the serotonin transporter.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 5.71 | 5.99 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL503609 | — | — | 1 | 5.99 |
| CHEMBL519819 | — | — | 1 | 5.94 |
| CHEMBL520301 | — | — | 1 | 5.83 |
| CHEMBL482903 | — | — | 1 | 5.60 |
| CHEMBL483316 | — | — | 1 | 5.46 |
| CHEMBL520970 | — | — | 1 | 5.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL503609 | — | Ki | = | 1030.0 | nM | 5.99 |
| CHEMBL519819 | — | Ki | = | 1155.0 | nM | 5.94 |
| CHEMBL520301 | — | Ki | = | 1485.0 | nM | 5.83 |
| CHEMBL482903 | — | Ki | = | 2490.0 | nM | 5.60 |
| CHEMBL483316 | — | Ki | = | 3490.0 | nM | 5.46 |
| CHEMBL520970 | — | Ki | = | 3650.0 | nM | 5.44 |