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Assay Detail

CHEMBL964698

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]prazosin from alpha-1-adrenoceptor in Wistar rat cerebral cortex membrane
ChEMBL ↗
252
Total Activities
252
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Rattus norvegicus
Tissue Cerebral cortex
Subcellular Membrane
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545) ↗
Type UNCHECKED

Publication

Synthesis, alpha 1-adrenoceptor antagonist activity, and SAR study of novel arylpiperazine derivatives of phenytoin.
Handzlik J, Maciag D, Kubacka M, Mogilski S, Filipek B, Stadnicka K, Kieć-Kononowicz K.
Bioorg Med Chem (2008) 16 : 5982 -5998
PubMed 18490167 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 252 9.55 10.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL446070 — — 1 10.30
CHEMBL444520 — — 1 10.30
CHEMBL453881 — — 1 10.30
CHEMBL510759 — — 1 10.30
CHEMBL449601 — — 1 10.30
CHEMBL507908 — — 1 10.30
CHEMBL450125 — — 1 10.30
CHEMBL450004 — — 1 10.30
CHEMBL458786 — — 1 10.30
CHEMBL48163 — — 1 10.30
CHEMBL300094 — — 1 10.30
CHEMBL300093 — — 1 10.30
CHEMBL449130 — — 1 10.30
CHEMBL502607 — — 1 10.30
CHEMBL451389 — — 1 10.30
CHEMBL67478 — — 1 10.30
CHEMBL444712 — — 1 10.30
CHEMBL444167 — — 1 10.30
CHEMBL447092 — — 1 10.30
CHEMBL501810 — — 1 10.30
CHEMBL453002 — — 1 10.30
CHEMBL450098 — — 1 10.30
CHEMBL447216 — — 1 10.30
CHEMBL452976 — — 1 10.30
CHEMBL454867 — — 1 10.30
CHEMBL452850 — — 1 10.30
CHEMBL447351 — — 1 10.30
CHEMBL116323 — — 1 10.30
CHEMBL331049 — — 1 10.30
CHEMBL117996 — — 1 10.30

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL447351 — Ki = 0.05 nM 10.30
CHEMBL451389 — Ki = 0.05 nM 10.30
CHEMBL446070 — Ki = 0.05 nM 10.30
CHEMBL444712 — Ki = 0.05 nM 10.30
CHEMBL444167 — Ki = 0.05 nM 10.30
CHEMBL447092 — Ki = 0.05 nM 10.30
CHEMBL501810 — Ki = 0.05 nM 10.30
CHEMBL453002 — Ki = 0.05 nM 10.30
CHEMBL450098 — Ki = 0.05 nM 10.30
CHEMBL447216 — Ki = 0.05 nM 10.30
CHEMBL452976 — Ki = 0.05 nM 10.30
CHEMBL454867 — Ki = 0.05 nM 10.30
CHEMBL452850 — Ki = 0.05 nM 10.30
CHEMBL502607 — Ki = 0.05 nM 10.30
CHEMBL116323 — Ki = 0.05 nM 10.30
CHEMBL331049 — Ki = 0.05 nM 10.30
CHEMBL117996 — Ki = 0.05 nM 10.30
CHEMBL66172 — Ki = 0.05 nM 10.30
CHEMBL67478 — Ki = 0.05 nM 10.30
CHEMBL502327 — Ki = 0.05 nM 10.30
CHEMBL452931 — Ki = 0.05 nM 10.30
CHEMBL304783 — Ki = 0.05 nM 10.30
CHEMBL500200 — Ki = 0.05 nM 10.30
CHEMBL506483 — Ki = 0.05 nM 10.30
CHEMBL67201 — Ki = 0.05 nM 10.30
CHEMBL444520 — Ki = 0.05 nM 10.30
CHEMBL504347 — Ki = 0.05 nM 10.30
CHEMBL447200 — Ki = 0.05 nM 10.30
CHEMBL49152 — Ki = 0.05 nM 10.30
CHEMBL300092 — Ki = 0.05 nM 10.30
CHEMBL445455 — Ki = 0.05 nM 10.30
CHEMBL455521 — Ki = 0.05 nM 10.30
CHEMBL444213 — Ki = 0.05 nM 10.30
CHEMBL501341 — Ki = 0.05 nM 10.30
CHEMBL450042 — Ki = 0.05 nM 10.30
CHEMBL443444 — Ki = 0.05 nM 10.30
CHEMBL454265 — Ki = 0.05 nM 10.30
CHEMBL505778 — Ki = 0.05 nM 10.30
CHEMBL66747 — Ki = 0.05 nM 10.30
CHEMBL453881 — Ki = 0.05 nM 10.30
CHEMBL510759 — Ki = 0.05 nM 10.30
CHEMBL449601 — Ki = 0.05 nM 10.30
CHEMBL507908 — Ki = 0.05 nM 10.30
CHEMBL450125 — Ki = 0.05 nM 10.30
CHEMBL450004 — Ki = 0.05 nM 10.30
CHEMBL458786 — Ki = 0.05 nM 10.30
CHEMBL48163 — Ki = 0.05 nM 10.30
CHEMBL300094 — Ki = 0.05 nM 10.30
CHEMBL300093 — Ki = 0.05 nM 10.30
CHEMBL449130 — Ki = 0.05 nM 10.30