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Assay Detail

CHEMBL964784

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human MCF7 cells after 96 hrs by SRB assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type MCF7
Confidence 1 — Organism
Curated By Autocuration

Target

MCF7 (CHEMBL387)
Type CELL-LINE
Organism Homo sapiens

Publication

Rational design of substituted diarylureas: a scaffold for binding to G-quadruplex motifs.
Drewe WC, Nanjunda R, Gunaratnam M, Beltran M, Parkinson GN, Reszka AP, Wilson WD, Neidle S.
J Med Chem (2008) 51 : 7751 -7767
PubMed 19053833 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 19 4.88 5.60

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL336434 1 5.60
CHEMBL446231 1 5.58
CHEMBL443513 1 5.50
CHEMBL447155 1 5.29
CHEMBL453250 1 4.96
CHEMBL297393 1 4.91
CHEMBL508572 1 4.84
CHEMBL499654 1 4.84
CHEMBL446600 1 4.71
CHEMBL449020 1 4.66
CHEMBL505459 1 4.62
CHEMBL452003 1 4.49
CHEMBL488275 1 4.47
CHEMBL508859 1 4.39
CHEMBL445182 1 4.30
CHEMBL448503 1 -
CHEMBL503558 1 -
CHEMBL502382 1 -
CHEMBL488276 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL336434 IC50 = 2500.0 nM 5.60
CHEMBL446231 IC50 = 2600.0 nM 5.58
CHEMBL443513 IC50 = 3200.0 nM 5.50
CHEMBL447155 IC50 = 5100.0 nM 5.29
CHEMBL453250 IC50 = 11100.0 nM 4.96
CHEMBL297393 IC50 = 12200.0 nM 4.91
CHEMBL508572 IC50 = 14400.0 nM 4.84
CHEMBL499654 IC50 = 14400.0 nM 4.84
CHEMBL446600 IC50 = 19500.0 nM 4.71
CHEMBL449020 IC50 = 21900.0 nM 4.66
CHEMBL505459 IC50 = 24200.0 nM 4.62
CHEMBL452003 IC50 = 32400.0 nM 4.49
CHEMBL488275 IC50 = 34100.0 nM 4.47
CHEMBL508859 IC50 = 40600.0 nM 4.39
CHEMBL445182 IC50 = 49600.0 nM 4.30
CHEMBL448503 IC50 - -
CHEMBL503558 IC50 - -
CHEMBL502382 IC50 > 50000.0 nM -
CHEMBL488276 IC50 > 25000.0 nM -