Assay Detail
Binding
CHEMBL964936
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of ErbB2 by SPA assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Receptor tyrosine-protein kinase erbB-2 (CHEMBL1824) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and evaluation of aniline headgroups for alkynyl thienopyrimidine dual EGFR/ErbB-2 kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.81 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL504117 | — | — | 1 | 7.52 |
| CHEMBL453398 | — | — | 1 | 7.22 |
| CHEMBL452768 | — | — | 1 | 6.92 |
| CHEMBL447720 | — | — | 1 | 5.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL504117 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL453398 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL452768 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL447720 | — | IC50 | = | 2660.0 | nM | 5.58 |