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Assay Detail

CHEMBL964951

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Binding
Inhibition of EphB4 by virtual HTS assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Intermediate

Target

Ephrin type-B receptor 4 (CHEMBL5147)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

N-substituted 2'-(aminoaryl)benzothiazoles as kinase inhibitors: hit identification and scaffold hopping.
Tasler S, Müller O, Wieber T, Herz T, Krauss R, Totzke F, Kubbutat MH, Schächtele C.
Bioorg Med Chem Lett (2009) 19 : 1349 -1356
PubMed 19211246 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 17 6.02 6.32

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL301018 1 6.32
CHEMBL460746 1 6.21
CHEMBL522785 1 6.11
CHEMBL514016 1 6.10
CHEMBL443906 1 6.08
CHEMBL473557 1 6.00
CHEMBL474543 1 5.85
CHEMBL473761 1 5.48
CHEMBL491686 1 -
CHEMBL514941 1 -
CHEMBL473553 1 -
CHEMBL473351 1 -
CHEMBL514942 1 -
CHEMBL473556 1 -
CHEMBL473354 1 -
CHEMBL490555 1 -
CHEMBL474544 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL301018 IC50 = 480.0 nM 6.32
CHEMBL460746 IC50 = 610.0 nM 6.21
CHEMBL522785 IC50 = 780.0 nM 6.11
CHEMBL514016 IC50 = 800.0 nM 6.10
CHEMBL443906 IC50 = 840.0 nM 6.08
CHEMBL473557 IC50 = 1000.0 nM 6.00
CHEMBL474543 IC50 = 1400.0 nM 5.85
CHEMBL473761 IC50 = 3300.0 nM 5.48
CHEMBL491686 IC50 > 10000.0 nM -
CHEMBL514941 IC50 > 10000.0 nM -
CHEMBL473553 IC50 > 10000.0 nM -
CHEMBL473351 IC50 > 10000.0 nM -
CHEMBL514942 IC50 > 10000.0 nM -
CHEMBL473556 IC50 > 10000.0 nM -
CHEMBL473354 IC50 > 10000.0 nM -
CHEMBL490555 IC50 > 10000.0 nM -
CHEMBL474544 IC50 > 10000.0 nM -