Assay Detail

CHEMBL965032

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Functional

Cytotoxicity against human SKOV3 cells

ChEMBL ↗

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Target

SK-OV-3 (CHEMBL614925) ↗

Open DB target context

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SK-OV-3 (CHEMBL614925) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target SK-OV-3

CHEMBL614925

Anchored from Assay target.

Protein identity SK-OV-3

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	SK-OV-3
Confidence	1 — Organism
Curated By	Autocuration

Target

SK-OV-3 (CHEMBL614925) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Kulokekahilide-2, a cytotoxic depsipeptide from a cephalaspidean mollusk Philinopsis speciosa.

Nakao Y, Yoshida WY, Takada Y, Kimura J, Yang L, Mooberry SL, Scheuer PJ.
J Nat Prod (2004) 67 : 1332 -1340
PubMed 15332851 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	8.12	8.12

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL507178	—	—	1	8.12

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL507178	—	IC50	=	7.5	nM	8.12