Assay Detail
Binding
CHEMBL965254
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Reduction of recombinant ECE2 activity measured by McaBk2 fluorescent substrate hydrolysis
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Homology modeling and site-directed mutagenesis to identify selective inhibitors of endothelin-converting enzyme-2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.94 | 5.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL487942 | — | — | 1 | 5.33 |
| CHEMBL487941 | — | — | 1 | 5.23 |
| CHEMBL127545 | — | — | 1 | 5.19 |
| CHEMBL488139 | — | — | 1 | 4.48 |
| CHEMBL488140 | — | — | 1 | 4.45 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL487942 | — | IC50 | = | 4630.0 | nM | 5.33 |
| CHEMBL487941 | — | IC50 | = | 5830.0 | nM | 5.23 |
| CHEMBL127545 | — | IC50 | = | 6420.0 | nM | 5.19 |
| CHEMBL488139 | — | IC50 | = | 32900.0 | nM | 4.48 |
| CHEMBL488140 | — | IC50 | = | 35700.0 | nM | 4.45 |