Assay Detail
Binding
CHEMBL965276
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Inhibition of HBV DNA polymerase
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Hepatitis B virus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Strong and selective inhibitors of hepatitis B virus replication among novel N4-hydroxy- and 5-methyl-beta-L-deoxycytidine analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.78 | 6.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL521050 | — | — | 1 | 6.68 |
| CHEMBL1230 | LAMIVUDINE TRIPHOSPHATE | -1.0 | 1 | 6.52 |
| CHEMBL1674 | TELBIVUDINE 5'TRIPHOSPHATE | -1.0 | 1 | 6.34 |
| CHEMBL483290 | — | — | 1 | 6.07 |
| CHEMBL483491 | — | — | 1 | 6.05 |
| CHEMBL486918 | — | — | 1 | 6.00 |
| CHEMBL483492 | — | — | 1 | 5.72 |
| CHEMBL486919 | — | — | 1 | 5.40 |
| CHEMBL520311 | — | — | 1 | 5.22 |
| CHEMBL503760 | — | — | 1 | 5.21 |
| CHEMBL519870 | — | — | 1 | 5.19 |
| CHEMBL483086 | — | — | 1 | 4.97 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL521050 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL1230 | LAMIVUDINE TRIPHOSPHATE | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL1674 | TELBIVUDINE 5'TRIPHOSPHATE | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL483290 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL483491 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL486918 | — | IC50 | = | 990.0 | nM | 6.00 |
| CHEMBL483492 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL486919 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL520311 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL503760 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL519870 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL483086 | — | IC50 | = | 10800.0 | nM | 4.97 |