Assay Detail
Functional
CHEMBL965744
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Growth inhibition of human AsPC1 cells after 72 hrs by MTT assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | ASPC1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Total synthesis and biological evaluation of novel C2-C6 region analogues of dictyostatin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.75 | 8.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL226880 | DICTYOSTATIN | — | 1 | 8.21 |
| CHEMBL461149 | — | — | 1 | 7.25 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 7.05 |
| CHEMBL459221 | — | — | 1 | 7.03 |
| CHEMBL479733 | — | — | 1 | 6.92 |
| CHEMBL474680 | — | — | 1 | 5.51 |
| CHEMBL475687 | — | — | 1 | 5.31 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL226880 | DICTYOSTATIN | IC50 | = | 6.2 | nM | 8.21 |
| CHEMBL461149 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL459221 | — | IC50 | = | 94.0 | nM | 7.03 |
| CHEMBL479733 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL474680 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL475687 | — | IC50 | = | 4900.0 | nM | 5.31 |