Assay Detail
Functional
CHEMBL965746
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Growth inhibition of human PANC1 cells after 72 hrs by MTT assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PANC-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Total synthesis and biological evaluation of novel C2-C6 region analogues of dictyostatin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.10 | 8.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL226880 | DICTYOSTATIN | — | 1 | 8.38 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 8.00 |
| CHEMBL461149 | — | — | 1 | 7.77 |
| CHEMBL459221 | — | — | 1 | 7.38 |
| CHEMBL479733 | — | — | 1 | 7.19 |
| CHEMBL226932 | — | — | 1 | 6.89 |
| CHEMBL474680 | — | — | 1 | 5.72 |
| CHEMBL475687 | — | — | 1 | 5.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL226880 | DICTYOSTATIN | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 9.9 | nM | 8.00 |
| CHEMBL461149 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL459221 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL479733 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL226932 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL474680 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL475687 | — | IC50 | = | 3200.0 | nM | 5.50 |