Assay Detail
Binding
CHEMBL965760
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Inhibition of histidine-tagged mouse MKP1 catalytic domain expressed in human Hela cells
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | HeLa |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Dual specificity protein phosphatase 1 (CHEMBL5623) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Bioactivities of simplified adociaquinone B and naphthoquinone derivatives against Cdc25B, MKP-1, and MKP-3 phosphatases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 5.00 | 6.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL50620 | — | — | 1 | 6.09 |
| CHEMBL476648 | ADOCIAQUINONE B | — | 1 | 5.96 |
| CHEMBL55934 | NAPHTHOQUINONE | — | 1 | 5.07 |
| CHEMBL274056 | NAPHTHAZALIN | — | 1 | 5.03 |
| CHEMBL43612 | JUGLONE | — | 1 | 4.89 |
| CHEMBL500348 | — | — | 1 | 4.75 |
| CHEMBL508233 | — | — | 1 | 4.66 |
| CHEMBL590 | MENADIONE | 4.0 | 1 | 4.62 |
| CHEMBL478485 | — | — | 1 | 4.47 |
| CHEMBL476655 | — | — | 1 | 4.41 |
| CHEMBL476649 | — | — | 1 | - |
| CHEMBL8320 | BENZOQUINONE | — | 1 | - |
| CHEMBL55659 | ANTHRAQUINONE | — | 1 | - |
| CHEMBL462058 | — | — | 1 | - |
| CHEMBL505950 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL50620 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL476648 | ADOCIAQUINONE B | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL55934 | NAPHTHOQUINONE | IC50 | = | 8450.0 | nM | 5.07 |
| CHEMBL274056 | NAPHTHAZALIN | IC50 | = | 9370.0 | nM | 5.03 |
| CHEMBL43612 | JUGLONE | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL500348 | — | IC50 | = | 17800.0 | nM | 4.75 |
| CHEMBL508233 | — | IC50 | = | 21800.0 | nM | 4.66 |
| CHEMBL590 | MENADIONE | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL478485 | — | IC50 | = | 33800.0 | nM | 4.47 |
| CHEMBL476655 | — | IC50 | = | 38700.0 | nM | 4.41 |
| CHEMBL476649 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL8320 | BENZOQUINONE | IC50 | > | 50000.0 | nM | - |
| CHEMBL55659 | ANTHRAQUINONE | IC50 | > | 50000.0 | nM | - |
| CHEMBL462058 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL505950 | — | IC50 | > | 50000.0 | nM | - |