Assay Detail
Binding
CHEMBL966201
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Inhibition of Mycobacterium tuberculosis fatty acid synthase 1 expressed in Mycobacterium smegmatis mc2 2700 assessed as NADPH oxidation using variable concentration of NADPH by spectrophotometry
4
Total Activities
2
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mycobacterium tuberculosis |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Inhibition of isolated Mycobacterium tuberculosis fatty acid synthase I by pyrazinamide analogs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 4.26 | 4.26 |
| IC50 | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL222382 | — | — | 2 | 4.26 |
| CHEMBL614 | PYRAZINAMIDE | 4.0 | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL222382 | — | Ki | = | 55000.0 | nM | 4.26 |
| CHEMBL614 | PYRAZINAMIDE | Ki | = | 2567000.0 | nM | - |
| CHEMBL614 | PYRAZINAMIDE | IC50 | = | 8930000.0 | nM | - |
| CHEMBL222382 | — | IC50 | = | 151000.0 | nM | - |