Assay Detail
Functional
CHEMBL966217
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Cytotoxicity against human A549 cells after 72 hrs by MTT assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel open-chain cytochalsins from the marine-derived fungus Spicaria elegans.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 4.51 | 5.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL472313 | CYTOCHALASIN Z11 | — | 1 | 5.37 |
| CHEMBL459866 | CYTOCHALASIN Z10 | — | 1 | 5.02 |
| CHEMBL458323 | CYTOCHALASIN Z13 | — | 1 | 4.12 |
| CHEMBL518476 | CYTOCHALASIN Z12 | — | 1 | 4.04 |
| CHEMBL469701 | — | — | 1 | 4.02 |
| CHEMBL460271 | CYTOCHALASIN Z15 | — | 1 | - |
| CHEMBL514120 | CYTOCHALASIN Z14 | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL472313 | CYTOCHALASIN Z11 | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL459866 | CYTOCHALASIN Z10 | IC50 | = | 9600.0 | nM | 5.02 |
| CHEMBL458323 | CYTOCHALASIN Z13 | IC50 | = | 76000.0 | nM | 4.12 |
| CHEMBL518476 | CYTOCHALASIN Z12 | IC50 | = | 92000.0 | nM | 4.04 |
| CHEMBL469701 | — | IC50 | = | 96000.0 | nM | 4.02 |
| CHEMBL460271 | CYTOCHALASIN Z15 | IC50 | > | 100000.0 | nM | - |
| CHEMBL514120 | CYTOCHALASIN Z14 | IC50 | > | 100000.0 | nM | - |