Assay Detail
Binding
CHEMBL966890
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Displacement of [125I][Tyr14]nociceptin from human cloned NOP receptor expressed in CHO cells
48
Total Activities
45
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
The discovery of tropane derivatives as nociceptin receptor ligands for the management of cough and anxiety.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 48 | 7.69 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL513136 | — | — | 1 | 9.52 |
| CHEMBL512414 | — | — | 1 | 8.77 |
| CHEMBL466067 | — | — | 1 | 8.72 |
| CHEMBL467314 | — | — | 1 | 8.70 |
| CHEMBL511920 | — | — | 1 | 8.64 |
| CHEMBL467488 | — | — | 1 | 8.57 |
| CHEMBL513471 | — | — | 1 | 8.52 |
| CHEMBL466679 | — | — | 1 | 8.52 |
| CHEMBL511374 | — | — | 1 | 8.52 |
| CHEMBL466847 | — | — | 1 | 8.47 |
| CHEMBL506634 | — | — | 1 | 8.44 |
| CHEMBL512258 | — | — | 1 | 8.40 |
| CHEMBL467497 | — | — | 1 | 8.31 |
| CHEMBL512411 | — | — | 1 | 8.28 |
| CHEMBL513660 | — | — | 1 | 8.28 |
| CHEMBL468952 | — | — | 1 | 8.22 |
| CHEMBL467313 | — | — | 1 | 8.22 |
| CHEMBL513667 | — | — | 1 | 8.15 |
| CHEMBL466126 | — | — | 1 | 8.14 |
| CHEMBL512247 | — | — | 1 | 8.13 |
| CHEMBL466846 | — | — | 1 | 8.12 |
| CHEMBL512950 | — | — | 1 | 8.10 |
| CHEMBL466693 | — | — | 1 | 8.09 |
| CHEMBL513171 | — | — | 2 | 8.00 |
| CHEMBL467699 | — | — | 1 | 8.00 |
| CHEMBL466694 | — | — | 1 | 7.96 |
| CHEMBL466919 | — | — | 1 | 7.96 |
| CHEMBL228690 | — | — | 1 | 7.89 |
| CHEMBL466066 | — | — | 1 | 7.89 |
| CHEMBL513303 | — | — | 1 | 7.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL513136 | — | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL512414 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL466067 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL467314 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL511920 | — | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL467488 | — | Ki | = | 2.7 | nM | 8.57 |
| CHEMBL513471 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL466679 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL511374 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL466847 | — | Ki | = | 3.4 | nM | 8.47 |
| CHEMBL506634 | — | Ki | = | 3.6 | nM | 8.44 |
| CHEMBL512258 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL467497 | — | Ki | = | 4.9 | nM | 8.31 |
| CHEMBL513660 | — | Ki | = | 5.3 | nM | 8.28 |
| CHEMBL512411 | — | Ki | = | 5.2 | nM | 8.28 |
| CHEMBL467313 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL468952 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL513667 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL466126 | — | Ki | = | 7.3 | nM | 8.14 |
| CHEMBL512247 | — | Ki | = | 7.4 | nM | 8.13 |
| CHEMBL466846 | — | Ki | = | 7.5 | nM | 8.12 |
| CHEMBL512950 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL466693 | — | Ki | = | 8.2 | nM | 8.09 |
| CHEMBL513171 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL467699 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL466919 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL466694 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL228690 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL466066 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL513303 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL466921 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL511373 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL467119 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL512612 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL467131 | — | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL511223 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL468953 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL467933 | — | Ki | = | 142.0 | nM | 6.85 |
| CHEMBL466438 | — | Ki | = | 198.0 | nM | 6.70 |
| CHEMBL466469 | — | Ki | = | 285.0 | nM | 6.54 |
| CHEMBL466082 | — | Ki | = | 385.0 | nM | 6.42 |
| CHEMBL467494 | — | Ki | = | 678.0 | nM | 6.17 |
| CHEMBL512982 | — | Ki | = | 908.0 | nM | 6.04 |
| CHEMBL466438 | — | Ki | = | 1090.0 | nM | 5.96 |
| CHEMBL467676 | — | Ki | = | 1571.0 | nM | 5.80 |
| CHEMBL511373 | — | Ki | = | 2999.0 | nM | 5.52 |
| CHEMBL506803 | — | Ki | = | 3151.0 | nM | 5.50 |
| CHEMBL513171 | — | Ki | = | 3759.0 | nM | 5.42 |