Assay Detail
Binding
CHEMBL966895
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]diprenorphine from human kappa opioid receptor expressed in CHO cells
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
The discovery of tropane derivatives as nociceptin receptor ligands for the management of cough and anxiety.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 6.59 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL466847 | — | — | 1 | 6.96 |
| CHEMBL513136 | — | — | 1 | 6.88 |
| CHEMBL512414 | — | — | 1 | 6.57 |
| CHEMBL228690 | — | — | 1 | 6.44 |
| CHEMBL466921 | — | — | 1 | 6.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL466847 | — | Ki | = | 109.0 | nM | 6.96 |
| CHEMBL513136 | — | Ki | = | 131.0 | nM | 6.88 |
| CHEMBL512414 | — | Ki | = | 268.0 | nM | 6.57 |
| CHEMBL228690 | — | Ki | = | 364.0 | nM | 6.44 |
| CHEMBL466921 | — | Ki | = | 752.0 | nM | 6.12 |