Assay Detail
Binding
CHEMBL968061
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [5,5'-3H2]AHPN from human recombinant GST-SHP by liquid scintillation counting relative to 3-Cl-AHPC
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Nuclear receptor subfamily 0 group B member 2 (CHEMBL5603) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Adamantyl-substituted retinoid-derived molecules that interact with the orphan nuclear receptor small heterodimer partner: effects of replacing the 1-adamantyl or hydroxyl group on inhibition of cancer cell growth, induction of cancer cell apoptosis, and inhibition of SRC homology 2 domain-containing protein tyrosine phosphatase-2 activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.75 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL461415 | — | — | 1 | 6.30 |
| CHEMBL459497 | — | — | 1 | 6.00 |
| CHEMBL176252 | — | — | 1 | 5.60 |
| CHEMBL460351 | — | — | 1 | 5.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL461415 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL459497 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL176252 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL460351 | — | IC50 | = | 8000.0 | nM | 5.10 |