Assay Detail
Binding
CHEMBL968063
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Inhibition of SHP2 overexpressed in human KG1 cells
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | KG-1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Tyrosine-protein phosphatase non-receptor type 11 (CHEMBL3864) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Adamantyl-substituted retinoid-derived molecules that interact with the orphan nuclear receptor small heterodimer partner: effects of replacing the 1-adamantyl or hydroxyl group on inhibition of cancer cell growth, induction of cancer cell apoptosis, and inhibition of SRC homology 2 domain-containing protein tyrosine phosphatase-2 activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.45 | 6.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL459711 | — | — | 1 | 6.35 |
| CHEMBL461827 | — | — | 1 | 5.74 |
| CHEMBL176252 | — | — | 1 | 5.68 |
| CHEMBL459497 | — | — | 1 | 5.68 |
| CHEMBL461415 | — | — | 1 | 5.64 |
| CHEMBL518627 | — | — | 1 | 5.41 |
| CHEMBL461620 | — | — | 1 | 5.34 |
| CHEMBL460351 | — | — | 1 | 5.27 |
| CHEMBL461199 | — | — | 1 | 5.19 |
| CHEMBL460350 | — | — | 1 | 4.99 |
| CHEMBL459712 | — | — | 1 | 4.70 |
| CHEMBL459710 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL459711 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL461827 | — | IC50 | = | 1830.0 | nM | 5.74 |
| CHEMBL176252 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL459497 | — | IC50 | = | 2110.0 | nM | 5.68 |
| CHEMBL461415 | — | IC50 | = | 2270.0 | nM | 5.64 |
| CHEMBL518627 | — | IC50 | = | 3910.0 | nM | 5.41 |
| CHEMBL461620 | — | IC50 | = | 4550.0 | nM | 5.34 |
| CHEMBL460351 | — | IC50 | = | 5370.0 | nM | 5.27 |
| CHEMBL461199 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL460350 | — | IC50 | = | 10200.0 | nM | 4.99 |
| CHEMBL459712 | — | IC50 | = | 19900.0 | nM | 4.70 |
| CHEMBL459710 | — | IC50 | = | 500000.0 | nM | - |